DNA-SEQUENCE, GENOMIC ORGANIZATION, AND CHROMOSOMAL LOCALIZATION OF THE MOUSE PERIPHERAL MYELIN PROTEIN ZERO GENE - IDENTIFICATION OF POLYMORPHIC ALLELES

被引：35

作者：

YOU, KH

HSIEH, CL

HAYES, C

STAHL, N

FRANCKE, U

POPKO, B

机构：

[1] UNIV N CAROLINA,DEPT BIOCHEM & BIOPHYS,PROGRAM MOLEC BIOL & BIOTECHNOL,CHAPEL HILL,NC 27599

[2] STANFORD UNIV,MED CTR,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305

[3] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305

[4] UNIV N CAROLINA,BRAIN & DEV RES CTR,CHAPEL HILL,NC 27599

来源：

GENOMICS | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90370-T

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned and characterized the mouse gene, P0, that encodes the predominant protein of peripheral myelin. Similar to the rat gene, the mouse P0 gene is encoded by six exons that span about 7 kb of DNA. The DNA sequence of the mouse gene is highly homologous with the rat gene, including the regions believed to be important in transcriptional control. Furthermore, the P0 protein appears well conserved throughout evolution. The gene was mapped to mouse chromosome 1 by Southern analysis of a Chinese hamster × mouse somatic cell hybrid panel. Several polymorphic restriction enzyme sites were identified within the P0 locus. Recombinant inbred strain mapping has linked the P0 gene to Ly-9/Ly-17/Sap in a region corresponding to band 1H3. © 1991.

引用

页码：751 / 757

页数：7

共 23 条

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