THE INFLUENCE OF AGING ON PLASMA SEX-HORMONES IN MEN - THE TELECOM-STUDY

被引：127

作者：

SIMON, D

PREZIOSI, P

BARRETTCONNOR, E

ROGER, M

SAINTPAUL, M

NAHOUL, K

PAPOZ, L

机构：

[1] FDN RECH HORMONOL, F-75014 PARIS, FRANCE

[2] DIRECT ACT SOCIALE ENFANCE & SANTE LABS, PARIS, FRANCE

[3] UNIV CALIF SAN DIEGO, DEPT COMMUNITY & FAMILY MED M007, LA JOLLA, CA 92093 USA

[4] HOP HENRI MONDOR, SERV ENDOCRINOL, F-94010 CRETEIL, FRANCE

[5] HOP HENRI MONDOR, DEPT SANTE PUBL, F-94010 CRETEIL, FRANCE

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 135卷 / 07期

关键词：

AGING; ESTRADIOL; ESTRONE; MEN; SEX HORMONES; TESTOSTERONE;

D O I：

10.1093/oxfordjournals.aje.a116365

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

From April 1985 to July 1987, 1,408 healthy white men aged 20-60 years in Paris, France, recruited on an occupational basis, underwent a physical examination and measurements of plasma sex hormones in a cross-sectional study. Both total testosterone and estradiol showed a significant stepwise decrease with age (p < 0.001) starting in the early adult years, while estrone did not vary. These relations of testosterone and estradiol with age remained significant after adjustment for body mass index, subscapular skinfold, and tobacco and alcohol consumptions, and they were not modified by exclusion of the men who reported chronic disease. Both the mechanism for the early decrease in testosterone and its clinical significance merit further investigation.

引用

页码：783 / 791

页数：9

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