学术探索
学术期刊
新闻热点
数据分析
智能评审

THE INFLUENCE OF AGING ON PLASMA SEX-HORMONES IN MEN - THE TELECOM-STUDY

被引：127
作者：
SIMON, D
PREZIOSI, P
BARRETTCONNOR, E
ROGER, M
SAINTPAUL, M
NAHOUL, K
PAPOZ, L
机构：
[1] FDN RECH HORMONOL, F-75014 PARIS, FRANCE
[2] DIRECT ACT SOCIALE ENFANCE & SANTE LABS, PARIS, FRANCE
[3] UNIV CALIF SAN DIEGO, DEPT COMMUNITY & FAMILY MED M007, LA JOLLA, CA 92093 USA
[4] HOP HENRI MONDOR, SERV ENDOCRINOL, F-94010 CRETEIL, FRANCE
[5] HOP HENRI MONDOR, DEPT SANTE PUBL, F-94010 CRETEIL, FRANCE
来源：
AMERICAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 135卷 / 07期
关键词：
AGING; ESTRADIOL; ESTRONE; MEN; SEX HORMONES; TESTOSTERONE;
D O I：
10.1093/oxfordjournals.aje.a116365
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
From April 1985 to July 1987, 1,408 healthy white men aged 20-60 years in Paris, France, recruited on an occupational basis, underwent a physical examination and measurements of plasma sex hormones in a cross-sectional study. Both total testosterone and estradiol showed a significant stepwise decrease with age (p < 0.001) starting in the early adult years, while estrone did not vary. These relations of testosterone and estradiol with age remained significant after adjustment for body mass index, subscapular skinfold, and tobacco and alcohol consumptions, and they were not modified by exclusion of the men who reported chronic disease. Both the mechanism for the early decrease in testosterone and its clinical significance merit further investigation.
引用
收藏
页码：783 / 791
页数：9
相关论文
共 53 条
[11]   RELATIONSHIP BETWEEN SEX-HORMONES AND HEMOSTATIC FACTORS IN HEALTHY MIDDLE-AGED MEN [J].
BONITHONKOPP, C ;
SCARABIN, PY ;
BARA, L ;
CASTANIER, M ;
JACQUESON, A ;
ROGER, M .
ATHEROSCLEROSIS, 1988, 71 (01) :71-76
[12]  
CASTANIER M, 1970, CR ACAD SCI D NAT, V271, P1787
[13]   ESTROGEN-ANDROGEN IMBALANCE IN HEPATIC CIRRHOSIS - STUDIES IN 13 MALE PATIENTS [J].
CHOPRA, IJ ;
TULCHINSKY, D ;
GREENWAY, FL .
ANNALS OF INTERNAL MEDICINE, 1973, 79 (02) :198-203
[14]   ALCOHOL-INDUCED DEFICITS IN THE HYPOTHALAMIC-PITUITARY-LUTEINIZING HORMONE AXIS IN THE MALE [J].
CICERO, TJ .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1982, 6 (02) :207-215
[15]   EFFECTS OF BODY-COMPOSITION AND EXERCISE CAPACITY ON GLUCOSE-TOLERANCE, INSULIN, AND LIPOPROTEIN LIPIDS IN HEALTHY OLDER MEN - A CROSS-SECTIONAL AND LONGITUDINAL INTERVENTION STUDY [J].
COON, PJ ;
BLEECKER, ER ;
DRINKWATER, DT ;
MEYERS, DA ;
GOLDBERG, AP .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (12) :1201-1209
[16]   TESTOSTERONE IN HUMAN PLASMA [J].
COPPAGE, WS ;
COONER, AE .
NEW ENGLAND JOURNAL OF MEDICINE, 1965, 273 (17) :902-&
[17]   CIGARETTE-SMOKING AND SERUM SEX-HORMONES IN MEN [J].
DAI, WS ;
GUTAI, JP ;
KULLER, LH ;
CAULEY, JA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 128 (04) :796-805
[18]   THE EPIDEMIOLOGY OF PLASMA TESTOSTERONE LEVELS IN MIDDLE-AGED MEN [J].
DAI, WS ;
KULLER, LH ;
LAPORTE, RE ;
GUTAI, JP ;
FALVOGERARD, L ;
CAGGIULA, A .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1981, 114 (06) :804-816
[19]   HORMONAL CHANGES AND SEXUAL FUNCTION IN AGING MEN [J].
DAVIDSON, JM ;
CHEN, JJ ;
CRAPO, L ;
GRAY, GD ;
GREENLEAF, WJ ;
CATANIA, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (01) :71-77
[20]   LEYDIG-CELL FUNCTION IN NORMAL MEN - EFFECT OF AGE, LIFE-STYLE, RESIDENCE, DIET, AND ACTIVITY [J].
DESLYPERE, JP ;
VERMEULEN, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 59 (05) :955-962
123456