ACTION OF CATHEPSIN-D ON HUMAN BETA-LIPOTROPIN - POSSIBLE SOURCE OF HUMAN BETA-MELANOTROPIN

被引：37

作者：

BARAT, E

PATTHY, A

GRAF, L

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 12期

关键词：

D O I：

10.1073/pnas.76.12.6120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala38-Ala37 peptide bonds of human β-lipotropin. It is suggested that the formation of human 'β-melanotropin' from γ-lipotropin, and that of γ-endophine from β-endorphin, is due to the action of cathepsin D during isolation procedures.

引用

页码：6120 / 6123

页数：4

共 24 条

[1]

Barrett A, 1977, PROTEINASES MAMMALIA, P209

[2]

BENUCK M, 1977, BRAIN RES, V143, P181

[3]

STUDIES ON PRIMARY STRUCTURE OF HUMAN BETA-LIPOTROPIC HORMONE [J].