A BRAIN SERINE THREONINE PROTEIN-KINASE ACTIVATED BY CDC42 AND RAC1

被引：1348

作者：

MANSER, E ^{[1
]}

LEUNG, T ^{[1
]}

SALIHUDDIN, H ^{[1
]}

ZHAO, ZS ^{[1
]}

LIM, L ^{[1
]}

机构：

[1] INST NEUROL,LONDON WC1N 1PJ,ENGLAND

来源：

NATURE | 1994年 / 367卷 / 6458期

关键词：

D O I：

10.1038/367040a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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页码：40 / 46

页数：7

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