AMINOSIDINE OINTMENTS FOR THE TREATMENT OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS

被引：31

作者：

NEAL, RA

MURPHY, AG

OLLIARO, P

CROFT, SL

机构：

[1] UCL HOSP, LONDON WC1E 6AU, ENGLAND

[2] LONDON SCH HYG & TROP MED, DEPT MED PARASITOL, LONDON WC1E 7HT, ENGLAND

[3] UNIV PAVIA, IRCCS S MATTEO, INST INFECT DIS, MILAN, ITALY

[4] FARMITALIA CARLO ERBA SPA, R & D ANTIINFECT, I-20159 MILAN, ITALY

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 02期

关键词：

D O I：

10.1016/0035-9203(94)90307-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective. The ointment containing urea was non-irritant to mice, whereas ointments containing quaternary ammonium compounds were irritant. The 15% AS/10% urea/WSP ointment was not effective in the treatment of L. mexicana or L. panamensis lesions on Balb/C mice, no cure being observed.

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页码：223 / 225

页数：3

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