ULTRASTRUCTURAL FEATURES OF NEUROENDOCRINE DIFFERENTIATED CARCINOMAS OF THE BREAST

被引：36

作者：

CAPELLA, C

USELLINI, L

PAPOTTI, M

MACRI, L

FINZI, G

EUSEBI, V

BUSSOLATI, G

机构：

[1] UNIV TURIN, DEPT BIOMED SCI & HUMAN ONCOL, SEZ ANAT PATOL, VIA SANTENA 7, I-10126 TURIN, ITALY

[2] UNIV PAVIA, DEPT HUMAN PATHOL, VARESE, ITALY

[3] UNIV BOLOGNA, INST PATHOL ANAT & HISTOL, I-40126 BOLOGNA, ITALY

来源：

ULTRASTRUCTURAL PATHOLOGY | 1990年 / 14卷 / 04期

关键词：

Breast neoplasms; Carcinoma; Chromogranin; Clear vesicles; Neuroendocrine; Ultrastructure;

D O I：

10.3109/01913129009032247

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

The ultrastructural patterns of neuroendocrine (NE) differentiated breast carcinomas are analyzed and discussed. Reports in the literature describe wide variations in the size of observed dense-core membrane-bound granules and discrepancies in their interpretation. In the present study 24 cases of breast carcinoma with recognized morphologic, histochemical, and immunocytochemical features of NE tumors were investigated. Five different types of dense-core granules of neurosecretory (NS) type (confirmed by the ultrastructural localization of chromogranin A) and five different cell types were recognized. Some amphicrine cells were found to contain both mucin and NS granules. Another notable ultrastructural feature of breast NE carcinomas was the presence of clear vesicles of presynaptic type, which correlated with expression of synaptophysin. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：321 / 334

页数：14

共 38 条

[11] DISTRIBUTION OF DENSE CORE GRANULES IN NORMAL, BENIGN AND MALIGNANT BREAST-TISSUE [J].