CALORIC RESTRICTION, AGING, AND ANTIOXIDANT ENZYMES

被引：69

作者：

FEUERS, RJ

WEINDRUCH, R

HART, RW

机构：

[1] NATL CTR TOXICOL RES,DIV BIOMETRY & RISK ASSESSMENT,JEFFERSON,AR 72079

[2] UNIV WISCONSIN,DEPT MED,MADISON,WI 53706

[3] GRECC,VA,MADISON,WI 53706

来源：

MUTATION RESEARCH | 1993年 / 295卷 / 4-6期

关键词：

ANTIOXIDANTS; AGING; CATALASE; FREE RADICALS; SUPEROXIDE DISMUTASE; CALORIC RESTRICTION;

D O I：

10.1016/0921-8734(93)90020-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The basic mechanisms of aging and its retardation by caloric restriction (CR) remain unclear. One suggested means by which CR could retard aging is based on production of mitochondrial free radicals, and efficiency of their subsequent metabolism. Currently, there is little information concerning the influences of age and CR on the rates of in vivo mitochondrial free radical production. However, evidence for CR-induced modulation of free radical detoxification capacities is mounting. The direction of the influence of CR on free radical detoxification is tissue-specific, These effects are broad and appear to provide positive advantage.

引用

页码：191 / 200

页数：10

共 60 条

[1] DELETERIOUS MITOCHONDRIAL-DNA MUTATIONS ACCUMULATE IN AGING HUMAN TISSUES [J].