AN IMMUNOHISTOCHEMICAL STUDY OF CATHEPSIN-E IN ALZHEIMER-TYPE DEMENTIA BRAINS

被引：40

作者：

BERNSTEIN, HG ^{[1
]}

WIEDERANDERS, B ^{[1
]}

机构：

[1] UNIV JENA,INST BIOCHEM,O-6900 JENA,GERMANY

来源：

BRAIN RESEARCH | 1994年 / 667卷 / 02期

关键词：

CATHEPSIN E; HUMAN BRAIN; ALZHEIMERS DISEASE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0006-8993(94)91509-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the immunohistochemical localization of cathepsin E (cath E) in the brains of patients with Alzheimer disease (AD) and control brains. In the normal brain cathepsin E immunoreactivity was detectable in a small number (below 5%) of neocortical and hippocampal neurons. In AD brains cathepsin E antigen was revealed in most large cortical and hippocampal pyramids and in neurons of the Nuc. basalis of Meynert. Cathepsin E was also present in cerebral microvessels, microglia, and in senile plaques. The enzyme might play roles in the process of neurodegeneration taking place in AD.

引用

页码：287 / 290

页数：4

共 23 条

[1] ANTIGEN PROCESSING FOR PRESENTATION BY CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX REQUIRES CLEAVAGE BY CATHEPSIN-E [J].