CARDIAC-FUNCTION IN GOATS EXPOSED TO CARBON-MONOXIDE

被引：11

作者：

JAMES, WE ^{[1
]}

TUCKER, CE ^{[1
]}

GROVER, RF ^{[1
]}

机构：

[1] UNIV COLORADO, SCH MED, CARDIOVASCULARPULM RES LAB, DENVER, CO 80262 USA

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 1979年 / 47卷 / 02期

关键词：

D O I：

10.1152/jappl.1979.47.2.429

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To investigate the possibility that prolonged carbon monoxide (CO) exposure would depress myocardial function, six chronically instrumented, unsedated goats were exposed to 160-200 ppm CO for 2 wk, resulting in a mean carboxyhemoglobin saturation of 20%. Cardiac index and stroke volume remained unchanged during and after exposure. Hematocrit and hemoglobin concentration started increasing on the 10th day of exposure, this increase reached statistical significance (P<0.05) on the 6th postexposure day. Contractility (Vmax) of the left ventricular myocardium and heart rate were unchanged during exposure to CO, but both were significantly (P<0.05) decreased at some time during the 1st week after removal from CO. If there was a decrease in intrinsic myocardial function during CO exposure, it may have been masked by increased sympathetic activity. The mechanism(s) that might produce the decrease in heart rate and contractility after removal from CO are not obvious.

引用

页码：429 / 434

页数：6

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