INDUCTION OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN BY TRANSFORMING GROWTH-FACTOR-BETA

被引:174
作者
TURNER, M
CHANTRY, D
KATSIKIS, P
BERGER, A
BRENNAN, FM
FELDMANN, M
机构
[1] CHARING CROSS SUNLEY MED RES CTR,DEPT IMMUNOL,LURGAN AVE,LONDON W6 8LW,ENGLAND
[2] UPJOHN CO,KALAMAZOO,MI 49001
关键词
D O I
10.1002/eji.1830210708
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Transforming growth factor-beta-1 (TGF-beta-1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF-beta-1 can stimulate the production of IL 6 and platelet-derived growth factor, indicating that TGF-beta-1 initiates complex effects on the production of cytokines. In this report we show that treatment of peripheral blood monocytes with TGF-beta-1 leads to the induction of a recently described IL 1 receptor antagonist protein (IRAP). The effect of TGF-beta-1 was both dose and time dependent. TGF-beta-1 induced de novo synthesis of IRAP, as Northern blotting experiments indicated a rapid and transient induction of the mRNA encoding IRAP. The induction of IRAP suggests a potential mechanism by which some of the inhibitory effects of TGF-beta-1 are mediated.
引用
收藏
页码:1635 / 1639
页数:5
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