INDUCTION OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN BY TRANSFORMING GROWTH-FACTOR-BETA

被引：174

作者：

TURNER, M

CHANTRY, D

KATSIKIS, P

BERGER, A

BRENNAN, FM

FELDMANN, M

机构：

[1] CHARING CROSS SUNLEY MED RES CTR,DEPT IMMUNOL,LURGAN AVE,LONDON W6 8LW,ENGLAND

[2] UPJOHN CO,KALAMAZOO,MI 49001

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 07期

关键词：

D O I：

10.1002/eji.1830210708

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor-beta-1 (TGF-beta-1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF-beta-1 can stimulate the production of IL 6 and platelet-derived growth factor, indicating that TGF-beta-1 initiates complex effects on the production of cytokines. In this report we show that treatment of peripheral blood monocytes with TGF-beta-1 leads to the induction of a recently described IL 1 receptor antagonist protein (IRAP). The effect of TGF-beta-1 was both dose and time dependent. TGF-beta-1 induced de novo synthesis of IRAP, as Northern blotting experiments indicated a rapid and transient induction of the mRNA encoding IRAP. The induction of IRAP suggests a potential mechanism by which some of the inhibitory effects of TGF-beta-1 are mediated.

引用

页码：1635 / 1639

页数：5

共 27 条

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