AN OPTICALLY-ACTIVE CHROMIUM(0)-COMPLEXED BENZALDEHYDE IN ORGANIC-SYNTHESIS - A HIGHLY STEREOCONTROLLED ASYMMETRIC-SYNTHESIS OF (2R,3S)-(-)-N-BENZOYL-3-PHENYLISOSERINE METHYL-ESTER, THE TAXOL C-13 SIDE-CHAIN ANALOG

被引：26

作者：

MUKAI, C

KIM, IJ

HANAOKA, M

机构：

[1] Faculty of Pharmaceutical Sciences, Kanazawa University Takara-machi, Kanazawa

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)86030-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An asymmetric aldol reaction of (+)-chromium(0)-complexed benzaldehyde 4 with the titanium enolate generated from the ethanethioate 5 provided the anti-aldol product 6 in a highly stereoselective manner, which was subsequently converted to the taxol C-13 side chain.

引用

页码：1007 / 1010

页数：4

共 19 条

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