THE SIGNAL TRANSDUCTION INDUCED BY THROMBIN IN HUMAN PLATELETS

被引：87

作者：

LAPETINA, EG

机构：

[1] Cell Biology Division, Burroughs Wellcome Co., Research Triangle Park

来源：

FEBS LETTERS | 1990年 / 268卷 / 02期

关键词：

3-inositol phospholipid; Heterotrimeric G protein; Phospholipase A[!sub]2[!/sub; Phospholipase C; Protein kinase A; Small molecular weight G protein;

D O I：

10.1016/0014-5793(90)81293-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Stimulation of human platelets by thrombin leads to the activation of phospholipases C and A2, protein kinases, formation of 3-inositol phos- pholipids and mobilization of Ca2+ . These biochemical reactions closely parallel platelet shape change, granular secretion and aggregation. The membrane-bound transducers for the thrombin receptor seem to be the heterotrimeric G protein G12 and the ras-related G protein rap 1-b. Phosphorylation of rap 1-b by the action of the cyclic AMP-dependent protein kinase seems to uncouple the thrombin receptor from phospholipases. This causes inhibition of the formation of second messenger molecules and the onset of physiological responses. © 1990.

引用

页码：400 / 404

页数：5