COMPARISON OF MASS-SPECTRAL TECHNIQUES USING ORGANIC PEROXIDES RELATED TO ARTEMISININ

被引：20

作者：

FALES, HM

SOKOLOSKI, EA

PANNELL, LK

PU, QL

KLAYMAN, DL

LIN, AJ

BROSSI, A

KELLEY, JA

机构：

[1] NIDDKD,BIOORGAN CHEM,BETHESDA,MD 20892

[2] WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307

[3] NIDDKD,CHEM LAB,BETHESDA,MD 20892

[4] NCI,MED CHEM LAB,BETHESDA,MD 20892

来源：

ANALYTICAL CHEMISTRY | 1990年 / 62卷 / 22期

关键词：

D O I：

10.1021/ac00221a016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The mass spectra of three peroxides related to artemisinin (1) are compared in nine different ionization modes. ion trap mass spectrometry (MS/MS) spectra reveal numerous pathways for the electron impact (EI) decompositions. In the EI mode, the best spectra are obtained by using the ion trap mass spectrometer at low temperatures. Loss of oxygen is observed with the other EI spectrometers, suggesting catalytic decomposition in the ion source. Methane positive and negative chemical Ionization (CI) spectra show considerable fragmentation, while Isobutane CI spectra show only (M + H)+ for 1 and (M + H − H20)+ for dihydroartemieinin (2) and (3). An unusually abundant (2M + H)+ is observed for 1 in both positive-ion plasma de sorption and fast atom bombardment mass spectra. © 1990, American Chemical Society. All rights reserved.

引用

页码：2494 / 2501

页数：8