EFFECT OF CLONIDINE ON BLOOD-PRESSURE AND GABAERGIC MECHANISMS IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：22

作者：

CZYZEWSKASZAFRAN, H ^{[1
]}

JASTRZEBSKI, Z ^{[1
]}

REMISZEWSKA, M ^{[1
]}

WUTKIEWICZ, M ^{[1
]}

机构：

[1] INST DRUG RES & CONTROL,DEPT PHARMACOL,30-34 CHELMSKA,PL-00725 WARSAW,POLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 198卷 / 2-3期

关键词：

CLONIDINE; BLOOD PRESSURE DECREASE; GABA (GAMMA-AMINOBUTYRIC ACID); SPONTANEOUSLY HYPERTENSIVE RAT (SHR); GABA-A RECEPTORS; GAD (GLUTAMIC ACID DECARBOXYLASE);

D O I：

10.1016/0014-2999(91)90609-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The action of clonidine on blood pressure and on the functional state of the gamma-aminobutyric acid-ergic (GABAergic) system was studied. A single injection of clonidine (1, 5, 10, 20-mu-g . kg-1) induced a dose-dependent decrease of blood pressure. Chronic administration of clonidine, 10-mu-g . kg-1, produced the maximum effect after the third injection. The effect was maintained for the duration of the study. Single or chronic clonidine injections, at the dose of 10-mu-g . kg-1 enhanced the GABA content in the brain and hypothalamus. This effect was less pronounced in the hippocampus. The drug administered according to the same regimen stimulated glutamic acid decarboxylase activity only in the hypothalamus. Clonidine caused a marked enhancement of specific [H-3]GABA binding in the hypothalamus. These data suggest that the hypotensive action of clonidine is related to stimulation of the GABAergic system.

引用

页码：115 / 120

页数：6

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