KILLING KINETICS OF 4 QUINOLONES AGAINST GRAM-POSITIVE COCCI

被引：20

作者：

CANTON, E ^{[1
]}

RAMON, MS ^{[1
]}

JIMENEZ, MT ^{[1
]}

MARTINEZ, JP ^{[1
]}

机构：

[1] UNIV VALENCIA, FAC FARM, SECC MICROBIOL, VALENCIA, SPAIN

来源：

CHEMOTHERAPY | 1993年 / 39卷 / 06期

关键词：

NORFLOXACIN; CIPROFLOXACIN; SPARFLOXACIN; TEMAFLOXACIN; QUINOLONE BACTERICIDAL ACTIVITY; PARADOXICAL EFFECT;

D O I：

10.1159/000238983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Killing kinetics of four fluoroquinolones against Staphylococcus species were determined during the first 5 h of incubation in the presence of drug concentrations ranging from the MIC to 1,024 mug/ml. Additionally, the relationship between killing rate and drug concentration was established. Sparfloxacin and temafloxacin were the most active quinolones assayed with greater lethal rates than ciprofloxacin and norfloxacin. The relation was biphasic with a decrease of at least 1 log10 c.f.u./ml at high drug concentrations with respect to that obtained at the optimal bactericidal concentration for all quinolone-microorganism combinations tested.

引用

页码：394 / 399

页数：6

共 33 条

[1] THE CLINICAL PROBLEMS OF BACTERIAL-RESISTANCE TO THE NEW QUINOLONES [J].

ACAR, JF ;

FRANCOUAL, S .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 :207-213

[2]

ANNEAR D I, 1982, Journal of Antimicrobial Chemotherapy, V10, P260, DOI 10.1093/jac/10.4.260

[3] CROSS-RESISTANCE AMONG CINOXACIN, CIPROFLOXACIN, DJ-6783, ENOXACIN, NALIDIXIC-ACID, NORFLOXACIN, AND OXOLINIC ACID AFTER INVITRO SELECTION OF RESISTANT POPULATIONS [J].

BARRY, AL ;

JONES, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (06) :775-777

[4] INVITRO ACTIVITY OF SPARFLOXACIN COMPARED WITH THOSE OF 5 OTHER QUINOLONES [J].

CANTON, E ;

PEMAN, J ;

JIMENEZ, MT ;

RAMON, MS ;

GOBERNADO, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (03) :558-565

[5]

CANTON E, 1991, J CHEMOTHER S4, V3, P65

[6] BIPHASIC KINETICS OF BACTERIAL KILLING BY QUINOLONES [J].

CARRET, G ;

FLANDROIS, JP ;

LOBRY, JR .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 27 (03) :319-327

[7] ANTIMICROBIAL ACTIVITY OF CIPROFLOXACIN AGAINST PSEUDOMONAS-AERUGINOSA, ESCHERICHIA-COLI, AND STAPHYLOCOCCUS-AUREUS DETERMINED BY THE KILLING CURVE METHOD - ANTIBIOTIC COMPARISONS AND SYNERGISTIC INTERACTIONS [J].

CHALKLEY, LJ ;

KOORNHOF, HJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (02) :331-342

[8] NALIDIXIC-ACID - ANTIBACTERIAL PARADOX [J].

CRUMPLIN, GC ;

SMITH, JT .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1975, 8 (03) :251-261

[9] DEVELOPMENT OF RESISTANCE TO CIPROFLOXACIN IN NUTRIENT-RICH AND NUTRIENT-LIMITED GROWTH-CONDITIONS INVITRO BY PSEUDOMONAS-AERUGINOSA ISOLATES FROM PATIENTS WITH CYSTIC-FIBROSIS [J].

FERGUSON, MI ;

SCOTT, EM ;

COLLIER, PS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (12) :2649-2651

[10] PARADOXICAL EFFECT OF PENICILLIN INVIVO [J].

GEORGE, RH ;

DYAS, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 17 (05) :684-685

← 1 2 3 4 →