EFFECTS OF PERFUSATE FLOW-RATE ON MEASURED BLOOD-VOLUME, DISSE SPACE, INTRACELLULAR WATER SPACE, AND DRUG EXTRACTION IN THE PERFUSED RAT-LIVER PREPARATION - CHARACTERIZATION BY THE MULTIPLE INDICATOR DILUTION TECHNIQUE

被引：85

作者：

PANG, KS

LEE, WF

CHERRY, WF

YUEN, V

ACCAPUTO, J

FAYZ, S

SCHWAB, AJ

GORESKY, CA

机构：

[1] UNIV TORONTO,FAC MED,TORONTO M5S 1A1,ONTARIO,CANADA

[2] MCGILL UNIV,MONTREAL GEN HOSP,MED CLIN,MONTREAL H3G 1A4,QUEBEC,CANADA

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1988年 / 16卷 / 06期

关键词：

D O I：

10.1007/BF01062014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：595 / 632

页数：38

共 54 条

[1] MODELS OF HEPATIC DRUG CLEARANCE - DISCRIMINATION BETWEEN THE WELL STIRRED AND PARALLEL-TUBE MODELS [J].

AHMAD, AB ;

BENNETT, PN ;

ROWLAND, M .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (04) :219-224

[2]

BABIAK LM, 1984, DRUG METAB DISPOS, V12, P698

[3]

BALLET F, 1987, J PHARMACOL EXP THER, V240, P303

[4]

BARON J, 1982, J BIOL CHEM, V256, P15200

[5] SATURATION KINETICS IN HEPATIC DRUG REMOVAL - A STATISTICAL APPROACH TO FUNCTIONAL-HETEROGENEITY [J].

BASS, L .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 244 (06) :G583-G589

[6] EFFECTS OF CAPILLARY HETEROGENEITY ON RATES OF STEADY UPTAKE OF SUBSTANCES BY THE INTACT LIVER [J].

BASS, L ;

ROBINSON, PJ .

MICROVASCULAR RESEARCH, 1981, 22 (01) :43-57

[7] HEPATIC ELIMINATION OF FLOWING SUBSTRATES - DISTRIBUTED MODEL [J].

BASS, L ;

ROBINSON, P ;

BRACKEN, AJ .

JOURNAL OF THEORETICAL BIOLOGY, 1978, 72 (01) :161-184

[8]

BASS L, 1985, CIRCULATION, V72, P47

[9] ETHANOL OXIDATION BY ISOLATED HEPATOCYTES FROM FED AND STARVED RATS AND FROM RATS EXPOSED TO ETHANOL, PHENOBARBITONE OR 3-AMINO-TRIAZOLE - NO EVIDENCE FOR A PHYSIOLOGICAL-ROLE OF A MICROSOMAL ETHANOL OXIDATION SYSTEM [J].

BERRY, MN ;

FANNING, DC ;

GRIVELL, AR ;

WALLACE, PG .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (16) :2161-2168

[10] INCREASED CLEARANCE OF ANTIPYRINE AND D-PROPRANOLOL AFTER PHENOBARBITAL TREATMENT IN MONKEY - RELATIVE CONTRIBUTIONS OF ENZYME-INDUCTION AND INCREASED HEPATIC BLOOD-FLOW [J].

BRANCH, RA ;

SHAND, DG ;

WILKINSON, GR ;

NIES, AS .

JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (04) :1101-1107

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