OUTCOMES OF BACTERIAL-MENINGITIS IN CHILDREN - A METAANALYSIS

被引:373
作者
BARAFF, LJ
LEE, SI
SCHRIGER, DL
机构
[1] UNIV CALIF LOS ANGELES, MED CTR, SCH MED, DEPT MED, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, MED CTR, SCH MED, DEPT PEDIAT, LOS ANGELES, CA 90024 USA
关键词
MENINGITIS (BACTERIAL); CHILDREN; OUTCOME ASSESSMENT; METAANALYSIS (ALL MESH TERMS);
D O I
10.1097/00006454-199305000-00008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We abstracted the results of all English language reports of the outcomes of bacterial meningitis published after 1955. We used hierarchical Bayesian meta-analysis to determine the overall and organism-specific frequencies of death and persistent neurologic sequelae in children 2 months to 19 years of age. A total of 4920 children with acute bacterial meningitis were included in 45 reports that met the inclusion criteria. Children described in the 19 reports of prospectively enrolled cohorts from developed countries had lower mortality (4.8% vs. 8.1%) and were more likely to have no sequelae (82.5% vs. 73.9%). In these 19 studies 1602 children were evaluated for at least 1 sequela after hospital discharge. The mean probabilities of these sequelae were: deafness, 10.5%; bilateral severe or profound deafness, 5.1%; mental retardation, 4.2%; spasticity and/or paresis, 3.5%; seizure disorder, 4.2%; and no detectable sequelae, 83.6%. Mean probabilities of outcomes varied significantly by etiologic bacteria, e.g. mortality: Haemophilus influenzae, 3.8%; Neisseria meningitidis, 7.5%; Streptococcus pneumoniae, 15.3%.
引用
收藏
页码:389 / 394
页数:6
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