TEMPORAL AND SPATIAL EXPRESSION OF LEUKEMIA INHIBITORY FACTOR IN RABBIT UTERUS DURING EARLY-PREGNANCY

被引：32

作者：

YANG, ZM ^{[1
]}

LE, SP ^{[1
]}

CHEN, DB ^{[1
]}

HARPER, MJK ^{[1
]}

机构：

[1] BAYLOR COLL MED, CTR REPROD MED & SURG, DEPT OBSTET & GYNECOL, HOUSTON, TX 77030 USA

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 1994年 / 38卷 / 02期

关键词：

LEUKEMIA INHIBITORY FACTOR; RABBIT; ENDOMETRIUM; BLASTOCYST IMPLANTATION; PREGNANCY;

D O I：

10.1002/mrd.1080380205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to document the appearance of LIF in the rabbit uterus during early pregnancy and to determine whether changes just prior to implantation, similar to those in mice, oc curred. LIF was localized in endometrial epithelium, myometrium, and endometrial glands. A low level of LIF was detected in the uterus of nonestrous and estrous females. LIF expression reached its highest level on day 5 of pregnancy and declined on days 6 and 7. By day 13 of pregnancy, little endometrial LIF was apparent. The expression of LIF on day 5 of pseudopregnancy was similar to that on day 5 of pregnancy. LIF expression was much higher at implantation sites than that at nonimplantation areas on day 7 of pregnancy. It is concluded that LIF may be important for the implantation of rabbit blastocysts. (C) 1994 Wiley-Liss, Inc.

引用

页码：148 / 152

页数：5

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