MUTAGENIC EFFECTS OF ISONICOTINIC-ACID HYDRACIDE IN FANCONIS ANEMIA

被引：27

作者：

SCHROEDER, TM

STAHLMAUGE, C

机构：

[1] Institut für Anthropologie und Humangenetik, Universität Heidelberg, Heidelberg, D-6900

来源：

HUMAN GENETICS | 1979年 / 52卷 / 03期

关键词：

D O I：

10.1007/BF00278680

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Isonicotinic acid hydracide (INH) increases substantially the chromosomal instability in Fanconi's anemia (FA) cells. The same concentrations of INH do not significantly break chromosomes in heterozygous or normal cells. INH does not induce alkylation or cross-links in the DNA like other mutagens known to increase breakage in FA cells. Possible mechanisms of the effect of INH are discussed. One consequence of this experiment is the possibility of an exact and doubtless prenatal diagnosis of a homozygous FA fetus. © 1979 Springer-Verlag.

引用

页码：309 / 321

页数：13

共 28 条

[1]

ARLETT CF, 1978, DNA REPAIR MECHANISM, P633

[2] CARCINOGEN-INDUCED CHROMOSOME BREAKAGE IN FANCONIS ANEMIA HETEROZYGOUS CELLS [J].