LEISHMANIA-DONOVANI - PURIFICATION AND PARTIAL CHARACTERIZATION OF A GLYCOPHOSPHOSPHINGOLIPID ANTIGEN EXPRESSED ON PROMASTIGOTE SURFACE

被引：5

作者：

DEMAJUMDAR, T

机构：

来源：

EXPERIMENTAL PARASITOLOGY | 1992年 / 74卷 / 03期

关键词：

LEISHMANIA DONOVANI; KALA-AZAR; GLYCOPHOSPHOSPHINGOLIPID; MEMBRANE ANTIGEN; CERAMIDE ANCHOR;

D O I：

10.1016/0014-4894(92)90148-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A ceramide-anchored glycophosphosphingolipid antigen was isolated from the lipid extract of Leishmania donovani promastigotes. The affinity-purified glycolipid antigen contained galactose, man nose, myo-inositol, phosphate, ceramide, and hexosamine but no sialic acid. The phosphate group was present internally at the core of the structure: inositol (1-O)-phosphorylceramide. The phosphate group became susceptible to alkaline phosphatase only after alkali-catalyzed hydrolysis of the glycolipid. © 1992.

引用

页码：251 / 260

页数：10