1ST SYNTHESIS OF A STRAINED 14-MEMBERED BIARYL ETHER LACTONE BY MACROLACTONIZATION

被引：30

作者：

JUSTUS, K ^{[1
]}

STEGLICH, W ^{[1
]}

机构：

[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,GERHARD DOMAGK STR 1,W-5300 BONN 1,GERMANY

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)93554-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of biaryl ether lactone 3 by macrolactonization of hydroxy acid 8 under defined Mitsunobu conditions is described. In accord with the literature, attempts to cyclize 8 via carboxyl activation failed.

引用

页码：5781 / 5784

页数：4

共 26 条

[21] SYNTHESIS OF MACROLIDES
NICOLAOU, KC
[J]. TETRAHEDRON, 1977, 33 (07) : 683 - 710
[22] CANNABIS .22. SYNTHESIS OF SPIRO-COMPOUNDS
NOVAK, J
SALEMINK, CA
[J]. TETRAHEDRON LETTERS, 1981, 22 (11) : 1063 - 1064
[23] RECENT DEVELOPMENTS IN THE TOTAL SYNTHESIS OF MACROLIDE ANTIBIOTICS
PATERSON, I
MANSURI, MM
[J]. TETRAHEDRON, 1985, 41 (18) : 3569 - 3624
[24] SEEBACH D, 1990, LIEBIGS ANN CHEM, P1007
[25] ANTINEOPLASTIC AGENTS .206. STRUCTURE OF THE CYTOSTATIC MACROCYCLIC LACTONE COMBRETASTATIN-D-2
SINGH, SB
PETTIT, GR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (09) : 2797 - 2800
[26] STEGLICH W, 1990, CIBA F SYMP, V154, P56

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