EXPRESSION OF MSL-2 CAUSES ASSEMBLY OF DOSAGE COMPENSATION REGULATORS ON THE X-CHROMOSOMES AND FEMALE LETHALITY IN DROSOPHILA

被引：259

作者：

KELLEY, RL

SOLOVYEVA, I

LYMAN, LM

RICHMAN, R

SOLOVYEV, V

KURODA, MI

机构：

[1] Howard Hughes Medical Institute Department, Cell Biology Baylor College of Medicine Houston

来源：

CELL | 1995年 / 81卷 / 06期

关键词：

D O I：

10.1016/0092-8674(95)90007-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male-specific lethal-2 (msl-2) is a RING finger protein that is required for X chromosome dosage compensation in Drosophila males. Consistent with the formation of a dosage compensation protein complex, msl-2 colocalizes with the other MSL proteins on the male X chromosome and coimmunoprecipitates with msl-1 from male larval extracts. Ectopic expression of msl-2 in females results in the appearance of the other MSL dosage compensation regulators on the female X chromosomes and decreased female viability. We suggest that msl-2 RNA is the primary target of Sxl regulation in the dosage compensation pathway and present a speculative model for the regulation of two distinct modes of dosage compensation by Sxl.

引用

页码：867 / 877

页数：11

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