EXPRESSION OF MSL-2 CAUSES ASSEMBLY OF DOSAGE COMPENSATION REGULATORS ON THE X-CHROMOSOMES AND FEMALE LETHALITY IN DROSOPHILA

被引：259

作者：

KELLEY, RL

SOLOVYEVA, I

LYMAN, LM

RICHMAN, R

SOLOVYEV, V

KURODA, MI

机构：

[1] Howard Hughes Medical Institute Department, Cell Biology Baylor College of Medicine Houston

来源：

CELL | 1995年 / 81卷 / 06期

关键词：

D O I：

10.1016/0092-8674(95)90007-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male-specific lethal-2 (msl-2) is a RING finger protein that is required for X chromosome dosage compensation in Drosophila males. Consistent with the formation of a dosage compensation protein complex, msl-2 colocalizes with the other MSL proteins on the male X chromosome and coimmunoprecipitates with msl-1 from male larval extracts. Ectopic expression of msl-2 in females results in the appearance of the other MSL dosage compensation regulators on the female X chromosomes and decreased female viability. We suggest that msl-2 RNA is the primary target of Sxl regulation in the dosage compensation pathway and present a speculative model for the regulation of two distinct modes of dosage compensation by Sxl.

引用

页码：867 / 877

页数：11

共 53 条

[31] IDENTIFICATION AND PRELIMINARY CHARACTERIZATION OF A PROTEIN MOTIF RELATED TO THE ZINC FINGER
LOVERING, R
HANSON, IM
BORDEN, KLB
MARTIN, S
OREILLY, NJ
EVAN, GI
RAHMAN, D
PAPPIN, DJC
TROWSDALE, J
FREEMONT, PS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) : 2112 - 2116
[32] THE LINK BETWEEN DOSAGE COMPENSATION AND SEX-DIFFERENTIATION IN DROSOPHILA-MELANOGASTER
LUCCHESI, JC
SKRIPSKY, T
[J]. CHROMOSOMA, 1981, 82 (02) : 217 - 227
[33] STUDIES ON THE SEX-SPECIFIC LETHALS OF DROSOPHILA-MELANOGASTER .7. SEX-SPECIFIC LETHALS THAT DO NOT AFFECT DOSAGE COMPENSATION
OKUNO, T
SATOU, T
OISHI, K
[J]. JAPANESE JOURNAL OF GENETICS, 1984, 59 (03): : 237 - 247
[34] PALMER MJ, 1993, GENETICS, V134, P545
[35] SEX-SPECIFIC REGULATION OF THE MALE-SPECIFIC LETHAL-1 DOSAGE COMPENSATION GENE IN DROSOPHILA
PALMER, MJ
RICHMAN, R
RICHTER, L
KURODA, MI
[J]. GENES & DEVELOPMENT, 1994, 8 (06) : 698 - 706
[36] Mechanisms of heritable gene repression during development of Drosophila
Paro, Renato
[J]. CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (06) : 999 - 1005
[37] CONTROL OF DROSOPHILA SEX-LETHAL PRE-MESSENGER-RNA SPLICING BY ITS OWN FEMALE-SPECIFIC PRODUCT
SAKAMOTO, H
INOUE, K
HIGUCHI, I
ONO, Y
SHIMURA, Y
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (21) : 5533 - 5540
[38] RNA-BINDING BY SXL PROTEINS IN-VITRO AND IN-VIVO
SAMUELS, ME
BOPP, D
COLVIN, RA
ROSCIGNO, RF
GARCIABLANCO, MA
SCHEDL, P
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) : 4975 - 4990
[39] THE COMPLEX SET OF LATE TRANSCRIPTS FROM THE DROSOPHILA SEX DETERMINATION GENE SEX-LETHAL ENCODES MULTIPLE RELATED POLYPEPTIDES
SAMUELS, ME
SCHEDL, P
CLINE, TW
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (07) : 3584 - 3602
[40] THE LIM DOMAIN IS A MODULAR PROTEIN-BINDING INTERFACE
SCHMEICHEL, KL
BECKERLE, MC
[J]. CELL, 1994, 79 (02) : 211 - 219

← 1 2 3 4 5 6 →