REVISION OF THE CONFIGURATION AT C-7 OF SALUTARIDINOL-I, THE NATURAL INTERMEDIATE IN MORPHINE BIOSYNTHESIS

被引：16

作者：

LOTTER, H ^{[1
]}

GOLLWITZER, J ^{[1
]}

ZENK, MH ^{[1
]}

机构：

[1] UNIV MUNICH,INST PHARMAZEUT BIOL,W-8000 MUNICH 2,GERMANY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)92210-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biologically active reduction product of salutaridine, which was generated by synthesis and by a highly substrate specific enzyme from Papaver somniferum, was shown by X-ray crystallography to have the opposite configuration at C-7 as hitherto assumed. The (7S)-configured biologically active alkaloid will be called in future salutaridinol, its inactive epimer, 7-epi-salutaridinol.

引用

页码：2443 / 2446

页数：4

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