ANXIOLYTIC-LIKE AND ANTINOCICEPTIVE EFFECTS OF MK-801 ACCOMPANIED BY SEDATION AND ATAXIA IN PRIMATES

被引：25

作者：

RUPNIAK, NMJ

BOYCE, S

TYE, S

COOK, G

IVERSEN, SD

机构：

[1] Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park, Eastwick Road

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 44卷 / 01期

关键词：

NMDA RECEPTOR; ANALGESIA; ANXIETY; SEDATION;

D O I：

10.1016/0091-3057(93)90293-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Anxiolytic-like and antinociceptive activities of the noncompetitive NMDA receptor antagonist MK-801 (dizocilpine) were compared with sedative and ataxic side effects in primates. Administration of MK-801 (0.1 mg/kg) caused taming in cynomolgus monkeys and increased tail withdrawal latencies in squirrel monkeys; both effects were accompanied by sedation and ataxia. These findings are discussed in relation to the possible therapeutic uses of NMDA antagonists and differences in the behavioural effects of such compounds in primate and rodent species.

引用

页码：153 / 156

页数：4

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