CALCIUM-CHANNEL BLOCKER-LIKE ACTION OF 1,9-DIDEOXYFORSKOLIN IN VASCULAR SMOOTH-MUSCLE

被引：6

作者：

ABE, A ^{[1
]}

KARAKI, H ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, DEPT VET PHARMACOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 60卷 / 04期

关键词：

1,9-DIDEOXYFORSKOLIN; CYTOSOLIC CA-2+ LEVEL; VASCULAR SMOOTH MUSCLE;

D O I：

10.1254/jjp.60.389

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibitory effect of 1,9-dideoxyforskolin (DFK) on the contraction of rat aorta was compared with that of forskolin. DFK inhibited the contraction induced by high K+ more strongly than that induced by norepinephrine, whereas forskolin more strongly inhibited the norepinephrine-induced contraction. The inhibitory effect of DFK on high K+-induced contraction was antagonized by an increase in extracellular Ca2+ concentration. DFK inhibited the increase in cytosolic Ca2+ level and contraction in parallel whereas forskolin inhibited the contraction more strongly than the cytosolic Ca2+ level. These results suggest that DFK, but not forskolin, inhibits vascular smooth muscle contraction by a Ca2+ channel blocker-like action.

引用

页码：389 / 392

页数：4

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