INVOLVEMENT OF HEME COMPONENTS IN STEROL-METABOLISM OF SACCHAROMYCES-CEREVISIAE

被引：56

作者：

LORENZ, RT ^{[1
]}

PARKS, LW ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT MICROBIOL,RALEIGH,NC 27695

来源：

LIPIDS | 1991年 / 26卷 / 08期

关键词：

D O I：

10.1007/BF02536423

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are involved in demethylation and desaturation steps. Regulatory effects of hemes on sterol formation have been demonstrated using specifically defective mutants of yeast. Heme competency participates in a mechanism whereby wild-type cells are prevented from taking exogenous sterols from the growth media. The multiple interactions of hemes and sterols appear to be associated with the variously defined functions for sterols in the yeast cells.

引用

收藏

页码：598 / 603

页数：6

相关论文

共 52 条

[21] THE ISOLATION OF 2 MUTANTS OF SACCHAROMYCES-CEREVISIAE WHICH DEMONSTRATE INCREASED ACTIVITY OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE [J].

DOWNING, JF ;

BURROWS, LS ;

BARD, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 94 (03) :974-979

[22] COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY [J].

ENDO, A ;

KURODA, M ;

TANZAWA, K .

FEBS LETTERS, 1976, 72 (02) :323-326

[23]

GOLLUB EG, 1977, J BIOL CHEM, V252, P2846

[24] INVOLVEMENT OF CYTOCHROME-P-450 IN DELTA-22-DESATURATION IN ERGOSTEROL BIOSYNTHESIS OF YEAST [J].

HATA, S ;

NISHINO, T ;

KOMORI, M ;

KATSUKI, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 103 (01) :272-277

[25] OXYGEN REQUIREMENTS FOR FORMATION AND ACTIVITY OF THE SQUALENE EPOXIDASE IN SACCHAROMYCES-CEREVISIAE [J].

JAHNKE, L ;

KLEIN, HP .

JOURNAL OF BACTERIOLOGY, 1983, 155 (02) :488-492

[26] CONTROL OF ERGOSTEROL BIOSYNTHESIS IN YEAST [J].

KAWAGUCHI, A .

JOURNAL OF BIOCHEMISTRY, 1970, 67 (02) :219-+

[27] STEROL CONTROL OF THE PHOSPHATIDYLETHANOLAMINE-PHOSPHATIDYLCHOLINE CONVERSION IN THE YEAST MUTANT GL7 [J].

KAWASAKI, S ;

RAMGOPAL, M ;

CHIN, J ;

BLOCH, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) :5715-5719

[28] PLEIOTROPIC MUTATIONS IN SACCHAROMYCES-CEREVISIAE AFFECTING STEROL UPTAKE AND METABOLISM [J].

LEWIS, TL ;

KEESLER, GA ;

FENNER, GP ;

PARKS, LW .

YEAST, 1988, 4 (02) :93-106

[29] STRUCTURAL DISCRIMINATION IN THE SPARKING FUNCTION OF STEROLS IN THE YEAST SACCHAROMYCES-CEREVISIAE [J].

LORENZ, RT ;

CASEY, WM ;

PARKS, LW .

JOURNAL OF BACTERIOLOGY, 1989, 171 (11) :6169-6173

[30]

OSUMI T, 1979, J BIOCHEM-TOKYO, V85, P819

← 1 2 3 4 5 6 →