MULLERIAN INHIBITING SUBSTANCE AS A MARKER FOR OVARIAN SEX-CORD TUMOR

被引：106

作者：

GUSTAFSON, ML

LEE, MM

SCULLY, RE

MONCURE, AC

HIRAKAWA, T

GOODMAN, A

MUNTZ, HG

DONAHOE, PK

MACLAUGHLIN, DT

FULLER, AF

机构：

[1] MASSACHUSETTS GEN HOSP,PEDIAT SURG RES LAB,WARREN 11,BOSTON,MA 02114

[2] MASSACHUSETTS GEN HOSP,VINCENT RES LAB,BOSTON,MA 02114

[3] MASSACHUSETTS GEN HOSP,DEPT SURG,BOSTON,MA 02114

[4] MASSACHUSETTS GEN HOSP,DEPT PEDIAT,BOSTON,MA 02114

[5] MASSACHUSETTS GEN HOSP,DEPT PATHOL,BOSTON,MA 02114

[6] MASSACHUSETTS GEN HOSP,DEPT OBSTET & GYNECOL,BOSTON,MA 02114

[7] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1992年 / 326卷 / 07期

关键词：

D O I：

10.1056/NEJM199202133260707

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MüLLERIAN inhibiting substance is a glycoprotein hormone produced by fetal Sertoli cells that causes regression of the müllerian ducts in males during sexual differentiation.1 2 3 Serum concentrations of this hormone remain high in boys for several years, but then decline by puberty.4 During normal female development, in the absence of müllerian inhibiting substance, the müllerian ducts give rise to the fallopian tubes, uterus, and upper third of the vagina.1 Postnatally, granulosa cells also secrete this hormone,5 resulting in serum concentrations in pubertal girls and women that are similar to those in men. A potential role for müllerian inhibiting substance in the. . . © 1992, Massachusetts Medical Society. All rights reserved.

引用

页码：466 / 471

页数：6

共 27 条

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