IDENTIFICATION OF TRANSACTIVATION-RESPONSE SEQUENCES IN THE LONG TERMINAL REPEAT OF BOVINE IMMUNODEFICIENCY-LIKE VIRUS

被引：22

作者：

CARPENTER, S ^{[1
]}

NADINDAVIS, SA ^{[1
]}

WANNEMUEHLER, Y ^{[1
]}

ROTH, JA ^{[1
]}

机构：

[1] AGR CANADA,ANIM DIS RES INST,NEPEAN K2H 8P9,ONTARIO,CANADA

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 07期

关键词：

D O I：

10.1128/JVI.67.7.4399-4403.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transient expression assays using the reporter gene that encodes chloramphenicol acetyltransferase were used to identify cis-acting sequences necessary for bovine immunodeficiency-like virus (BIV) transactivation. Computer analyses identified two RNA stem-loop structures located immediately downstream of the transcription start site in the long terminal repeat. Deletion analysis of the long terminal repeat indicated that sequences containing the proximal stem-loop structure located between +4 and +31 are required for virus-specific transactivation. Therefore, BIV likely utilizes a mechanism of transactivation similar to that of the human and simian lentiviruses.

引用

页码：4399 / 4403

页数：5