REACTIONS OF ORGANOCUPRATES WITH VINYL-TRIFLATES AND RELATED CEPHEMS - A NOVEL-APPROACH TO 3-SUBSTITUTED CEPHALOSPORINS

被引：18

作者：

KANT, J

SAPINO, C

BAKER, SR

机构：

[1] Chemical Process Development Pharmaceutical Research and Development Div. Bristol-Myers Squibb Co., Syracuse

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)97404-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Vinyl-triflates and related 3-substituted cephems readily undergo addition-elimination reactions with a variety of organocuprates to form new carbon-carbon bonds. This chemistry presents a novel approach to the synthesis of 3-alkyl, 3-aryl, and 3-alkenylcephalosporins. © 1990.

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页码：3389 / 3392

页数：4

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