(-)DEPRENYL AND (-)PARAFLUORODEPRENYL-TREATMENT PREVENTS AGE-RELATED PIGMENT CHANGES IN THE SUBSTANTIA-NIGRA - A TV-IMAGE ANALYSIS OF NEUROMELANIN

被引：22

作者：

KNOLL, J ^{[1
]}

TOTH, V ^{[1
]}

KUMMERT, M ^{[1
]}

SUGAR, J ^{[1
]}

机构：

[1] NATL INST ONCOL,BUDAPEST,HUNGARY

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1992年 / 63卷 / 02期

关键词：

(-)DEPRENYL; (-)PARAFLUORODEPRENYL; NEUROCYTES IN SUBSTANTIA-NIGRA; NEUROMELANIN; PREVENTION OF AGE-RELATED PIGMENT CHANGES;

D O I：

10.1016/0047-6374(92)90061-H

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the aid of TV-image analysis the number, the area and the density features of melanin granules in neurocytes of the substantia nigra in a group of 3-month-old naive male rats and in a 2 1 -month-old group of male rats treated for 18 months with saline, (-)deprenyl and (-)parafluorodeprenyl, respectively, were determined. According to the Kolmogorov 2-sample test the two drug-treated groups do not differ significantly from each other in the number, total area and area of one pigment granule. In the aged saline-treated group the number of melanin granules decreased significantly and the area of the melanin granules increased in comparison to young controls as well as to the drug-treated groups.

引用

页码：157 / 163

页数：7

共 18 条

[1] INCREASED LIFE EXPECTANCY RESULTING FROM ADDITION OF L-DEPRENYL TO MADOPAR TREATMENT IN PARKINSONS-DISEASE - A LONGTERM STUDY [J].