A DRAMATIC CHANGE IN THE INTERACTION OF CU(II) WITH BIO-PEPTIDES PROMOTED BY SDS - A MODEL FOR COMPLEX-FORMATION ON A MEMBRANE-SURFACE

被引：21

作者：

BAL, W

KOZLOWSKI, H

LISOWSKI, M

PETTIT, L

ROBBINS, R

SAFAVI, A

机构：

[1] UNIV WROCLAW,INST CHEM,PL-50383 WROCLAW,POLAND

[2] UNIV LEEDS,AS SCH CHEM,LEEDS,ENGLAND

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1994年 / 55卷 / 01期

关键词：

D O I：

10.1016/0162-0134(94)85131-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extent of complex formation between Cu(II) and many biologically active oligopeptides has been shown to change significantly in the presence of SDS micelles, a recognized model for cell lipid membranes. Protonation constants of peptides can be increased by up to 2 log unit, especially when they contain hydrophobic side chains. Metal complex formation is generally less extensive and the conformations of peptides can be altered dramatically when compared to those in simple aqueous solution.

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页码：41 / 52

页数：12

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