TUMOR LOCALIZING AGENTS .7. RADIOIODINATED QUINOLINE DERIVATIVES

被引：24

作者：

COUNSELL, RE

POCHA, P

RANADE, VV

STERNGOLD, J

BEIERWALTES, WH

机构：

[1] Laboratory of Medicinal Chemistry, College of Pharmacy, Department of Medicine (Nuclearr Medicine), University of Michigan, Ann Arbor

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 02期

关键词：

D O I：

10.1021/jm00302a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several radioiodinated analogs of chloroquiiio were synthesized in an effort-to find an agent which would selectively localize in melanomas. One compound, 4-(3-dimethylamiiiopvopylanmino)-7-iodoquinoline-125I was found to have a marked affinity for melanin-containing tissues and for melanotic tumors in animals. © 1969, American Chemical Society. All rights reserved.

引用

页码：232 / +

页数：1

共 24 条

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[2] BEIERWAL.WH, 1968, J LAB CLIN MED, V72, P485
[3] VISUALIZING HUMAN MALIGNANT MELANOMA AND METASTASES - USE OF CHLOROQUINE ANALOG TAGGED WITH IODINE 125
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[4] BEIERWALTES WH, 1968, J NUCL MED, V9, P489
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[7] MELANIN BINDING PROPERTIES OF IODOQUINE
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[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1968, 50 (03) : 250 - &
[8] COHEN SN, 1965, J BIOL CHEM, V240, P3123
[9] TUMOR LOCALIZING AGENTS .3. RADIOIODINATED QUINOLINE DERIVATIVES
COUNSELL, RE
POCHA, P
MORALES, JO
BEIERWAL.WH
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (08) : 1042 - &
[10] TUMOR LOCALIZING AGENTS .6. RADIOIODINATED ANALOGS OF DICHLORODIPHENYLDICHLOROETHANE (DDD)
COUNSELL, RE
RANADE, VV
POCHA, P
WILLETTE, RE
DIGUILIO, W
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (10) : 1657 - &

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