BACTERIAL ENDOTOXIN-INDUCED EXPRESSION OF METALLOTHIONEIN GENES IN RAT-BRAIN, AS REVEALED BY INSITU HYBRIDIZATION

被引：49

作者：

ITANO, Y

NOJI, S

KOYAMA, E

TANIGUCHI, S

TAGA, N

TAKAHASHI, T

ONO, K

KOSAKA, F

机构：

[1] OKAYAMA UNIV, SCH DENT, DEPT BIOCHEM, OKAYAMA 700, JAPAN

[2] OKAYAMA UNIV, SCH MED, DEPT ANAT, OKAYAMA 700, JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 124卷 / 01期

关键词：

METALLOTHIONEIN; ENDOTOXIN; LIPOPOLYSACCHARIDE; ACUTE-PHASE; BRAIN; INSITU HYBRIDIZATION;

D O I：

10.1016/0304-3940(91)90811-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to clarify acute-phase response in brain, we investigated induction of metallothionein (MT) genes by administrating an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and glial cells around the Purkinje cells of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in brain. These results suggest that the acute-phase response occurs specifically in at least these 3 non-neuronal cells.

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页码：13 / 16

页数：4

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