THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

被引：215

作者：

WINSTANLEY, J

COOKE, T

MURRAY, GD

PLATTHIGGINS, A

GEORGE, WD

HOLT, S

MYSKOV, M

SPEDDING, A

BARRACLOUGH, BR

RUDLAND, PS

机构：

[1] UNIV GLASGOW,DEPT SURG,GLASGOW G12 8QQ,SCOTLAND

[2] UNIV LIVERPOOL,DEPT SURG,LIVERPOOL L69 3BX,ENGLAND

[3] DEPT BIOCHEM,LIVERPOOL,ENGLAND

[4] BROADGREEN HOSP,DEPT PATHOL,LIVERPOOL L14 3LB,MERSEYSIDE,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 03期

关键词：

D O I：

10.1038/bjc.1991.103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

引用

页码：447 / 450

页数：4