POSITRON EMISSION TOMOGRAPHY OF MONOCLONAL-ANTIBODIES

A review on the use of monoclonal antibodies labeled with positron emitting nuclides is presented. Potential radionuclides for labeling are e.g. F-18, Co-55, Cu-64, Ga-66, Ga-68, Br-76, Zr-89 and I-124. Radionuclides with short half-lives may be utilized especially by pretargeting approaches. Gallium-isotopes have also been coupled to antibodies, using chelation methods. One promising nuclide for antibody labeling seems to be I-124 (t(1/2) = 4.2 d) as radioiodination of antibodies is a well-characterized procedure. Some of our own studies using I-124 labeled monoclonal antibodies in a nude mouse and rat human ovarian cancer xenograft are reported.