POSITRON EMISSION TOMOGRAPHY OF MONOCLONAL-ANTIBODIES

被引：14

作者：

KAIREMO, KJA

机构：

[1] Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki

来源：

ACTA ONCOLOGICA | 1993年 / 32卷 / 7-8期

关键词：

D O I：

10.3109/02841869309096142

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A review on the use of monoclonal antibodies labeled with positron emitting nuclides is presented. Potential radionuclides for labeling are e.g. F-18, Co-55, Cu-64, Ga-66, Ga-68, Br-76, Zr-89 and I-124. Radionuclides with short half-lives may be utilized especially by pretargeting approaches. Gallium-isotopes have also been coupled to antibodies, using chelation methods. One promising nuclide for antibody labeling seems to be I-124 (t(1/2) = 4.2 d) as radioiodination of antibodies is a well-characterized procedure. Some of our own studies using I-124 labeled monoclonal antibodies in a nude mouse and rat human ovarian cancer xenograft are reported.

引用

页码：825 / 830

页数：6

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