TRANSIENT SHIFT OF DIACYLGLYCEROL AND INOSITOL LIPIDS INDUCED BY INTERFERON IN DAUDI CELLS - EVIDENCE FOR A DIFFERENT PATTERN BETWEEN NUCLEI AND INTACT-CELLS

被引：38

作者：

CATALDI, A

MISCIA, S

LISIO, R

RANA, R

COCCO, L

机构：

[1] UNIV CHIETI, IST MORFOL UMANA NORMALE, CHIETI, ITALY

[2] CNR, IST CITOMORFOL NORMALE & PATOL, CHIETI, ITALY

来源：

FEBS LETTERS | 1990年 / 269卷 / 02期

关键词：

Daudi cell; Diacylglycerol; Inositol lipid; Interferon;

D O I：

10.1016/0014-5793(90)81216-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of human recombinant DNA interferon-α type A on inositol lipid and diacylglycerol metabolism was investigated in Daudi lymphoma whole cells and isolated nuclei. In isolated nuclei after 90 min of interferon treatment an enhanced rate of PIP2 phosphorylation and an increase of DAG mass were observed. In whole cells, after 1 min of interferon treatment, there was a rapid and transient shift of DAG mass apparently not related to inositol lipid modifications, thus indicating the presence in nuclear and cytoplasmic compartments of inositol lipid fractions with different metabolic features in response to interferon-α. © 1990.

引用

页码：465 / 468

页数：4

共 14 条

[11]

MISCIA S, 1988, Medical Science Research, V16, P807

[12]

MISCIA S, 1989, CELL BIOL INT REP, V13, P595

[13] EARLY MODIFICATIONS OF NUCLEIC-ACID METABOLISM AND NUCLEAR LIPID BIOSYNTHESIS ASSOCIATED WITH ANTIPROLIFERATIVE ACTIVITY OF INTERFERON-ALPHA ON DAUDI LYMPHOMA-CELLS [J].