A FACILE SYNTHESIS OF CHIRAL N-PROTECTED BETA-AMINO ALCOHOLS

被引：172

作者：

RODRIGUEZ, M ^{[1
]}

LLINARES, M ^{[1
]}

DOULUT, S ^{[1
]}

HEITZ, A ^{[1
]}

MARTINEZ, J ^{[1
]}

机构：

[1] CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,RUE CARDONILLE,F-34094 MONTPELLIER 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)92121-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral N-protected beta-amino alchols are easily obtained by NaBH4 reduction of mixed anhydrides of N-protected alpha-amino acids in an organic/aqueous medium. The alcohols obtained from side chain or main chain reduction of N-protected aspartic acid are converted in good yields into lactones.

引用

页码：923 / 926

页数：4

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