CLONAL 6P21 REARRANGEMENT IS RESTRICTED TO THE MESENCHYMAL COMPONENT OF AN ENDOMETRIAL POLYP

被引：51

作者：

FLETCHER, JA

PINKUS, JL

LAGE, JM

MORTON, CC

PINKUS, GS

机构：

[1] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT PEDIAT ONCOL, BOSTON, MA 02115 USA

[2] CHILDRENS HOSP MED CTR, DEPT HEMATOL ONCOL, BOSTON, MA 02115 USA

[3] CHILDRENS HOSP MED CTR, DEPT PATHOL, BOSTON, MA 02115 USA

[4] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[5] HARVARD UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02115 USA

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 5卷 / 03期

关键词：

D O I：

10.1002/gcc.2870050315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

引用

页码：260 / 263

页数：4

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