THE EFFECT OF DIETARY-LIPID CHANGES ON THE FATTY-ACID COMPOSITION AND FUNCTION OF LIVER, HEART AND BRAIN MITOCHONDRIA IN THE RAT AT DIFFERENT AGES

被引：56

作者：

BARZANTI, V

BATTINO, M

BARACCA, A

CAVAZZONI, M

COCCHI, M

NOBLE, R

MARANESI, M

TURCHETTO, E

LENAZ, G

机构：

[1] UNIV ANCONA, INST BIOCHEM, I-60100 ANCONA, ITALY

[2] SCOTTISH AGR COLL, DEPT BIOCHEM SCI, AUCHINCRUIVE KA6 5HW, AYR, SCOTLAND

来源：

BRITISH JOURNAL OF NUTRITION | 1994年 / 71卷 / 02期

关键词：

FAT INTAKE; MITOCHONDRIAL FATTY ACIDS; METABOLIC ENZYMES;

D O I：

10.1079/BJN19940126

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

A correlation between dietary lipids and cellular enzyme activities is a problem that has only been partially addressed by nutritionists. Therefore, changes in the fatty acid composition and the activities of some key metabolic enzymes (ubiquinol-2-cytochrome c reductase (EC 1.10.2.2), cytochrome oxidase (EC 1.9.3.1) and ATPase (EC 3.6.1.3)) in the mitochondria of liver, heart and brain of rats fed on diets differing extensively in their polyunsaturated fatty acid compositions have been investigated. The results showed that fatty acid compositional changes brought about by the dietary differences were associated with extensive changes in the activities of these key enzymes in the mitochondria. The extent of the influence differed considerably with the period over which the diets were fed. The role of dietary lipids to effect changes through the preservation of membrane structural integrity is discussed.

引用

页码：193 / 202

页数：10

共 28 条

[1] EFFECT OF LIPIDS HAVING DIFFERENT N-6 AND N-3 FATTY-ACID CONTENTS ON SOME ORGANS AND SUBCELLULAR STRUCTURES OF THE RAT [J].