INCREASED PLATELET-ACTIVATING-FACTOR SYNTHESIS IN EXPERIMENTAL COLITIS AFTER DICLOFENAC AND 5-AMINOSALICYLIC ACID

被引：5

作者：

ZIJLSTRA, FJ ^{[1
]}

VANDIJK, JPM ^{[1
]}

WILSON, JHP ^{[1
]}

机构：

[1] ACAD HOSP ROTTERDAM DIJKZIGT,DEPT INTERNAL MED 2,ROTTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 249卷 / 01期

关键词：

EXPERIMENTAL COLITIS; PAF (PLATELET ACTIVATING FACTOR); 5-AMINOSALICYLIC ACID;

D O I：

10.1016/0014-2999(93)90672-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the role of platelet activating factor in dextran induced colitis in mice. The release of pro-inflammatory platelet activating factor by colonic mucosa after the application of prednisolone was markedly decreased, unaffected after treatment with the platelet activating factor receptor antagonist BN52021 and significantly increased after treatment with 5-amino-salicylic acid and diclofenac. This increase of platelet activating factor could be responsible for the harmful effects often seen after treatment with specific cyclooxygenase inhibitors during inflammation.

引用

页码：R1 / R2

页数：2

共 8 条

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