EFFECT OF NALOXONE OR LEVALLORPHAN ON SERUM PROLACTIN CONCENTRATIONS AND APOMORPHINE-INDUCED GROWTH-HORMONE SECRETION

被引：37

作者：

LAL, S ^{[1
]}

NAIR, NPV ^{[1
]}

CERVANTES, P ^{[1
]}

PULMAN, J ^{[1
]}

GUYDA, H ^{[1
]}

机构：

[1] MCGILL UNIV,DOUGLAS HOSP CTR,PROT & POLYPEPTIDE LAB,MONTREAL H3C 3G1,QUEBEC,CANADA

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1979年 / 59卷 / 02期

关键词：

apomorphine; dopaminergic mechanisms; grwoth hormone; hypothalamic‐pituitary axis; levallorphan; Naloxone; narcotic antagonist; prolactin;

D O I：

10.1111/j.1600-0447.1979.tb06959.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Naloxone HCL (0.8 mg intravenously; n= 9) or levallorphan tartrate (0.25 mg subcutaneously; n= 5) had no effect on basal prolactin or grwoth hormone secretion in normal men. Neither narcotic antagonist inhibited the grwoth hormone secretory response to apomorphine HCL (0.75 mg subcutaneously). These findings suggest that narcotic antagonists do not block dopamine receptors in the hypothalamic‐pituitary axis in man and that if these agents have antischizophrenic properties then these are not mediated by dopamine receptor blockade. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：173 / 179

页数：7

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