ANTICONVULSANT AND SLEEP-WAKING INFLUENCES OF RILUZOLE IN A RAT MODEL OF ABSENCE EPILEPSY

被引：37

作者：

ROMETTINO, S ^{[1
]}

LAZDUNSKI, M ^{[1
]}

GOTTESMANN, C ^{[1
]}

机构：

[1] UNIV NICE,FAC SCI,PSYCHOPHYSIOL LAB,PARC VALROSE,F-06034 NICE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 03期

关键词：

SPIKE-WAVE DISCHARGES; ABSENCE EPILEPSY; ANTICONVULSANT; SLEEP-WAKING; (RAT);

D O I：

10.1016/0014-2999(91)90503-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Six WAG/Rij rats, an animal model of human absence epilepsy, were injected intraperitoneally with riluzole. At 4 mg/kg, riluzole decreased the number, mean duration and spike-frequency of the spontaneously occurring discharges for 3 h. Riluzole also increased slow wave sleep at the expense of waking. As riluzole at 3 mg/kg decreased the number and spike-frequency of the discharges without inducing a sedative effect, this compound could be of therapeutic interest in human absence epilepsy.

引用

页码：371 / 373

页数：3

共 10 条

[1] 2-AMINO-6-TRIFLUOROMETHOXY BENZOTHIAZOLE, A POSSIBLE ANTAGONIST OF EXCITATORY AMINO-ACID NEUROTRANSMISSION .2. BIOCHEMICAL-PROPERTIES [J].

BENAVIDES, J ;

CAMELIN, JC ;

MITRANI, N ;

FLAMAND, F ;

UZAN, A ;

LEGRAND, JJ ;

GUEREMY, C ;

LEFUR, G .

NEUROPHARMACOLOGY, 1985, 24 (11) :1085-1092

[2] INVIVO PRESYNAPTIC CONTROL OF DOPAMINE RELEASE IN THE CAT CAUDATE-NUCLEUS .2. FACILITATORY OR INHIBITORY INFLUENCE OF L-GLUTAMATE [J].

CHERAMY, A ;

ROMO, R ;

GODEHEU, G ;

BARUCH, P ;

GLOWINSKI, J .

NEUROSCIENCE, 1986, 19 (04) :1081-1090

[3] THE WAG RIJ RAT MODEL FOR ABSENCE EPILEPSY - AGE AND SEX FACTORS [J].

COENEN, AML ;

VANLUIJTELAAR, ELJM .

EPILEPSY RESEARCH, 1987, 1 (05) :297-301

[4] EXCITATORY AMINO-ACID RECEPTORS IN EPILEPSY [J].

DINGLEDINE, R ;

MCBAIN, CJ ;

MCNAMARA, JO .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (08) :334-338

[5]

MALGOURIS C, 1989, J NEUROSCI, V9, P3720

[6] 2-AMINO-6-TRIFLUOROMETHOXY BENZOTHIAZOLE, A POSSIBLE ANTAGONIST OF EXCITATORY AMINO-ACID NEUROTRANSMISSION .1. ANTICONVULSANT PROPERTIES [J].

MIZOULE, J ;

MELDRUM, B ;

MAZADIER, M ;

CROUCHER, M ;

OLLAT, C ;

UZAN, A ;

LEGRAND, JJ ;

GUEREMY, C ;

LEFUR, G .

NEUROPHARMACOLOGY, 1985, 24 (08) :767-773

[7] INVOLVEMENT OF NMDA RECEPTORS IN NONCONVULSIVE EPILEPSY IN WAG/RIJ RATS [J].

PEETERS, BWMM ;

VANRIJN, CM ;

VOSSEN, JMH ;

COENEN, AML .

LIFE SCIENCES, 1990, 47 (06) :523-529

[8] RILUZOLE, A GLUTAMATE ANTAGONIST, ENHANCES SLOW-WAVE AND REM-SLEEP IN RATS [J].

STUTZMANN, JM ;

LUCAS, M ;

BLANCHARD, JC ;

LADURON, PM .

NEUROSCIENCE LETTERS, 1988, 88 (02) :195-200

[9] 2 TYPES OF ELECTROCORTICAL PAROXYSMS IN AN INBRED STRAIN OF RATS [J].

VANLUIJTELAAR, ELJM ;

COENEN, AML .

NEUROSCIENCE LETTERS, 1986, 70 (03) :393-397

[10] CIRCADIAN RHYTHMICITY IN ABSENCE EPILEPSY IN RATS [J].

VANLUIJTELAAR, ELJM ;

COENEN, AML .

EPILEPSY RESEARCH, 1988, 2 (05) :331-336

← 1 →