T(2 18) AND T(18 22) VARIANT CHROMOSOMAL TRANSLOCATIONS IN B-CELL MALIGNANCIES

被引：11

作者：

BERTHEAS, MF

BACHY, M

MAGAUD, JP

RIMOKH, R

VASSELON, C

BERGER, F

ORIOL, PC

JAUBERT, J

REYNAUD, J

BRIZARD, CP

GUYOTAT, D

机构：

[1] Département d'Hématologic, Hôpital Nord, Saint-Etienne, Lyon

[2] Laboratoire de Cytogénétique Moléculaire, Hôpital Edouard Herriot, Lyon

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 8卷 / 03期

关键词：

VARIANT TRANSLOCATION; BCL2; FOLLICULAR LYMPHOMA; CLL;

D O I：

10.3109/10428199209054905

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Variant translocations (2;18 and 18;22) are described in this review. The chromosomal and molecular findings of these translocations of BCL2 and their effect on possible BCL2 gene activation is discussed. Unanswered questions still remain and these include why this is so rare compared to the 25% incidence recorded for translocations in Burkitt's lymphoma. Further studies are obviously still needed in order to determine the true frequency of these findings and their distribution in the various B-cell disorders.

引用

页码：197 / 200

页数：4