EFFECT OF TREATMENT WITH VITAMIN-D3 ON THE RESPONSES OF THE DUODENUM OF SPONTANEOUSLY HYPERTENSIVE RATS TO BRADYKININ AND TO POTASSIUM

被引：14

作者：

FERES, T ^{[1
]}

VIANNA, LM ^{[1
]}

PAIVA, ACM ^{[1
]}

PAIVA, TB ^{[1
]}

机构：

[1] ESCOLA PAULISTA MED SCH,DEPT BIOPHYS,BR-04034 SAO PAULO,BRAZIL

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 105卷 / 04期

关键词：

BRADYKININ; DUODENUM; INTESTINAL SMOOTH MUSCLE; SPONTANEOUSLY HYPERTENSIVE RATS; VITAMIN-D;

D O I：

10.1111/j.1476-5381.1992.tb09072.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5-mu-g vitamin D3 100 g-1 body weight daily by gavage, for 14 days. 2 The blood pressure of the SHR treated with either calcium or vitamin D decreased to the same levels as that of WKY and NWR. 3 The response to bradykinin of the SHR isolated duodenum, which is predominantly contractile, upon treatment with vitamin D (but not with calcium), became predominantly relaxant, approaching the normal behaviour of the WKY and NWR duodenum. 4 The relaxant responses of the SHR and WKY duodenum to potassium were smaller than those of NWR, but treatment with vitamin D increased the response in all three rat strains. 5 It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin-dependent activation of calcium-dependent potassium channels.

引用

页码：881 / 884

页数：4