NITRIC-OXIDE AND CARBON-MONOXIDE PRODUCE ACTIVITY-DEPENDENT LONG-TERM SYNAPTIC ENHANCEMENT IN HIPPOCAMPUS

被引:504
作者
ZHUO, M
SMALL, SA
KANDEL, ER
HAWKINS, RD
机构
[1] COLUMBIA UNIV COLL PHYS & SURG,NEW YORK STATE PSYCHIAT INST,CTR NEUROBIOL & BEHAV,NEW YORK,NY 10032
[2] HOWARD HUGHES MED INST,NEW YORK,NY 10032
关键词
D O I
10.1126/science.8100368
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nitric oxide (NO) and carbon monoxide (CO) may act as retrograde messages for long-term potentiation (LTP) in the hippocampus. Zinc protoporphyrin IX, an inhibitor of the enzyme that produces CO, blocked induction of LTP in the CA1 region of hippocampal slices. Application of either NO or CO to slices produced a rapid and long-lasting increase in the size of evoked synaptic potentials if, and only if, the application occurred at the same time as weak tetanic stimulation. This long-term enhancement was spatially restricted to synapses from active presynaptic fibers and appeared to involve mechanisms utilized by LTP, occluding the subsequent induction of LTP by strong tetanic stimulation. The enhancement by NO and CO was not blocked by an N-methyl-D-aspartate (NMDA) receptor blocker, suggesting that NO and CO act downstream from the NMDA receptor. Also, CO produced long-term enhancement when paired with low-frequency stimulation. These results are consistent with the hypothesis that NO and CO, either alone or in combination, serve as retrograde messages that produce activity-dependent presynaptic enhancement during LTP.
引用
收藏
页码:1946 / 1950
页数:5
相关论文
共 40 条
  • [21] HAWKINS RD, 1990, SEMIN NEUROSCI, V2, P391
  • [22] HUANG YY, 1993, J NEUROSCI, V13, P568
  • [23] LI YG, 1992, SOC NEUR ABSTR, V18, P343
  • [24] OSTEOCLASTIC INHIBITION - AN ACTION OF NITRIC-OXIDE NOT MEDIATED BY CYCLIC-GMP
    MACINTYRE, I
    ZAIDI, M
    ALAM, ASMT
    DATTA, HK
    MOONGA, BS
    LIDBURY, PS
    HECKER, M
    VANE, JR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) : 2936 - 2940
  • [26] DOES CARBON-MONOXIDE HAVE A PHYSIOLOGICAL-FUNCTION
    MARKS, GS
    BRIEN, JF
    NAKATSU, K
    MCLAUGHLIN, BE
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (05) : 185 - 188
  • [27] TESTS OF THE ROLES OF 2 DIFFUSIBLE SUBSTANCES IN LONG-TERM POTENTIATION - EVIDENCE FOR NITRIC-OXIDE AS A POSSIBLE EARLY RETROGRADE MESSENGER
    ODELL, TJ
    HAWKINS, RD
    KANDEL, ER
    ARANCIO, O
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) : 11285 - 11289
  • [28] ODELL TT, COMMUNICATION
  • [29] PREVENTION OF NEONATAL HYPERBILIRUBINEMIA IN NON-HUMAN PRIMATES BY ZN-PROTOPORPHYRIN
    QATO, MK
    MAINES, MD
    [J]. BIOCHEMICAL JOURNAL, 1985, 226 (01) : 51 - 57
  • [30] SCHUMAN E M, 1991, Society for Neuroscience Abstracts, V17, P2