REINFORCED ALTERNATION PERFORMANCE IS IMPAIRED BY MUSCARINIC BUT NOT BY NICOTINIC RECEPTOR BLOCKADE IN RATS

被引：34

作者：

CLARKE, PBS ^{[1
]}

FIBIGER, HC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1W5,BC,CANADA

来源：

BEHAVIOURAL BRAIN RESEARCH | 1990年 / 36卷 / 03期

基金：

英国医学研究理事会;

关键词：

Cholinergic; Memory; Muscarinic; Nicotinic; Rat; Receptor;

D O I：

10.1016/0166-4328(90)90058-M

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In pre-trained rats, food-rewarded reinforced alternation in a T-maze was markedly impaired by scopolamine, but unaffected by the centrally-active nicotinic antagonist mecamylamine (0.2-6.3 mg/kg s.c.). The nicotinic antagonist chlorisondamine (10 μg i.v.t.) was also ineffective, despite demonstrated blockade of nicotine-induced locomotor depression. These results question the extent to which central nicotinic receptors are involved in memory function. © 1990.

引用

页码：203 / 207

页数：5